Geographic atrophy
As non-exduative AMD progresses in more advanced stages, the outer retinal layers become disrupted and develops atrophy. Drusen is reabsorbed and geographic atrophy develops that corresponds to decrease in central vision. SD-OCT scans of geographic atrophy, reveals RPE thinning, loss of EPIS and COST lines, depression of the inner retinal layers as the outer layers are loss, and increase visibility of Bruch's membrane and the choroid.
Figure 1. SD-OCT horizontal scan over the fovea in a patient with non-exudative AMD with geographic atrophy. There is loss of outer retinal layers including the RPE, EPIS line, COST line, ELM, and the outer nuclear layer. The Bruch's membrane and choroidal capillaris is visible due to the overlying outer retinal atrophy.
Figure 2. SD-OCT horizontal scan over the fovea in a patient with non-exudative AMD with subfoveal geographic atrophy. There is loss of outer retinal layers including the RPE, EPIS line, COST line, ELM, and the outer nuclear layer. The Bruch's membrane and choroidal capillaris is visible due to the overlying outer retinal atrophy.
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